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Year : 2000  |  Volume : 3  |  Issue : 2  |  Page : 60-64

Glomerular filtration rate in clinically stable nigerian preterm and term newborns

1 Department of Paediatrics, University of Ilorin Teaching Hospital, Nigeria
2 De partment of Paediatrics, University College Hospital Ibadan, Nigeria
3 Mount Sinai Hospital Chicago, United States of America, USA
4 Department of Chemical Pathology University of Ilorin Teaching Hospital, Nigeria

Correspondence Address:
O T Adedoyin
PMB 1459, Ilorin
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Source of Support: None, Conflict of Interest: None

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Objective: Published data on the evaluation of renal function in Nigerian Newborn are very few. This study aimed to establish baseline values of GFR in clinically stable Nigerian Preterm and Term Newborn of diJXerent sexes using the Schwartz formula. . Materials and Methods: The serum cretinine of eighty clinically stable, appropriate-for-gestational age (AGA) ewborn of different gestational ages were determined. Their glomerular filtration rate in ml/min/1.73m2 were derived using the Schwartz formula. The formula is GFR in ml/min/1.73m2 - Kl!Scr; where Lis length in centimetre I (em), Scr is serum creatinine in mg/dl and K is a constant. In low birth weight infant (<2.5kg) K "= 0.33, while it is .45 in full term, appropriate-for gestational age infant. Results: A mean GFR of 15.64ml/minll .73m2 was obtained in preterm babies as against 27. 24mllminll .73m2 in the term babies. Conclusion: A positive correlation existed between the GFR and the gestational ages. A significant difference was detected between the GFR values in preterm and term babies.

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