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Year : 2003  |  Volume : 6  |  Issue : 2  |  Page : 53-57

Serum levels of antioxidant vitamins in sicklers and non­ sicklers in Sokoto metropolis' children

1 Department of Biochemistry, Faculty of Science, Usmanu Danfodiyo University, P.M .B.2346 Sokoto, Nigeria
2 Department of Paediatrics, Usmanu Danfodiyo U niversity Teaching Hospital P.M.B.2370 Sokoto, Nigeria

Correspondence Address:
I K Matazu
Department of Biochemistry, Faculty of Science, Usmanu Danfodiyo University, P.M .B.2346 Sokoto
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Source of Support: None, Conflict of Interest: None

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The serum concentrations of vitamins A (retinol ), C ( ascorbic acid ) and E (alpha -tocopherol) of paediatric- age group were determined In sicklers and non-sicklers within the Sokoto metropolis. The levels of the antioxidant vitamins were found to be significantly lower (p < 0.001) In the slckler group when compared to that in non-sicklers. In all cases the concentrations of the antioxidant vitamins were significantly depressed In children with sickle-cell anaemia. The depletion In the levels of the three-antloxldant vitamins may probably account for some of the observed clinical manifestations of sickle-cell anaemia. This shall be the subject of our future lnvestigation(s).

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