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ORIGINAL ARTICLE
Year : 2005  |  Volume : 8  |  Issue : 3  |  Page : 71-75

Cd4+ lymphocyte reference ranges in healthy adults in port harcourt, Nigeria


1 Departments of Haematology, University of Port Harcourt Teaching Hospital, PMB 6173, Port Harcourt, Nigeria
2 Preventive and Social Medicine, University of Port Harcourt Teaching Hospital, PMB 6173, Port Harcourt, Nigeria

Correspondence Address:
O Erhabor
Department of Haematology, University of Port Harcourt Teaching Hospital, PMB 6173, Port Harcourt
Nigeria
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Source of Support: None, Conflict of Interest: None


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Aims and Objectives: Reference values are essential for the interpretation of data in clinical practice and research studies. The aim of this study was to establish reference ranges for CD4lymphocytes in healthy HIV-negative Nigerians. Methodology: 200 healthy Human Immunodeficiency Virus (HIV) antibody free individuals constituted the subjects for this study. 150 HIV-infected without AIDS-defining illness and 150 HIV-infected with AIDS-defining illness were included as controls. Results: Participants were aged 18-63years (mean age 34΁ 9.2years). the CD4 lymphocyte cou nt of healthy Nigerians mean΁ S D 685 ΁ 99, 95% CI 487- 883 was twice that of HIV-infected subjects without AIDS -defining illness (314 ΁ 45, 95% CI 224- 404). The CD4lymphocyte count of HIV-infected with AIDS-defining illness was one fourth or less (148 ΁ 30, 95% C/88 - 208). The mean AIDS-defining CD4lymphocyte count was (148 ΁ 30cells!ul). women had significantly higher mean absolute CD4 lymphocyte count (729 ΁ 87, 95% CI 555 to 903) compared to men ( 647 ΁ 93, 95% C/460 to 833) (p< 0.001). Age was found negatively correlated with CD4 lymphocyte count in healthy Nigerians (r = -.01, p< 0.05). the absolute CD4lymphocyte count and ranges of healthy H IV-negative Nigerians was significantly lower than those of Dutch and Ethiopian controls (p<0.05). Conclusion: Caucasian CD4 lymphocyte reference values are not applicable to Nigerians, as it does not reflect the Nigerian CD4 lymphocyte population. (Key words: CD4 lymphocyte count, Reference ranges, Port Harcourt, Nigerians).


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