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REVIEW ARTICLE
Year : 2011  |  Volume : 14  |  Issue : 3  |  Page : 113-118

The janus kinase 2 (JAK2) mutation: A review of its role in polycythaemia vera and other myeloproliferative disorders


Department of Haematology and Blood Transfusion, Faculty of Clinical Medicine, Delta State University, Abraka, Delta State

Correspondence Address:
M U Nwagu
Department of Haematology and Blood Transfusion, Faculty of Clinical Medicine, Delta State University,Abraka, Delta State

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Source of Support: None, Conflict of Interest: None


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Background: Unlike Chronic Myeloid Leukemia (CML) whose genetic basis (the Philadelphia chromosome), has become a household name, that of Polycythaemia Vera and other non-leukemic myeloproliferative diseases has not equally received wide publicity. Aim: The aim of this paper is to review and highlight the role of JAK2 mutation in Polycythaemia Vera, Primary Myelofibrosis and Essential Thrombocythaemia. Methods: Literature on the subject was reviewed using manual library search, articles in journals, internet search and conference abstracts. Results: JAK2 mutation plays important role in the general pathophysiology of non-leukemic myeloproliferative diseases. Proper understanding of these roles is being utilized in research and development of novel therapeutic agents.


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