REVIEW ARTICLE |
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Year : 2011 | Volume
: 14
| Issue : 3 | Page : 113-118 |
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The janus kinase 2 (JAK2) mutation: A review of its role in polycythaemia vera and other myeloproliferative disorders
MU Nwagu
Department of Haematology and Blood Transfusion, Faculty of Clinical Medicine, Delta State University, Abraka, Delta State
Correspondence Address:
M U Nwagu Department of Haematology and Blood Transfusion, Faculty of Clinical Medicine, Delta State University,Abraka, Delta State
Source of Support: None, Conflict of Interest: None | Check |
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Background: Unlike Chronic Myeloid Leukemia (CML) whose genetic basis (the Philadelphia chromosome), has become a household name, that of Polycythaemia Vera and other non-leukemic myeloproliferative diseases has not equally received wide publicity.
Aim: The aim of this paper is to review and highlight the role of JAK2 mutation in Polycythaemia Vera, Primary Myelofibrosis and Essential Thrombocythaemia.
Methods: Literature on the subject was reviewed using manual library search, articles in journals, internet search and conference abstracts.
Results: JAK2 mutation plays important role in the general pathophysiology of non-leukemic myeloproliferative diseases. Proper understanding of these roles is being utilized in research and development of novel therapeutic agents. |
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