Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Home Print this page Email this page
Users Online:: 824
REVIEW ARTICLE
Year : 2011  |  Volume : 14  |  Issue : 3  |  Page : 113-118

The janus kinase 2 (JAK2) mutation: A review of its role in polycythaemia vera and other myeloproliferative disorders


Department of Haematology and Blood Transfusion, Faculty of Clinical Medicine, Delta State University, Abraka, Delta State

Correspondence Address:
M U Nwagu
Department of Haematology and Blood Transfusion, Faculty of Clinical Medicine, Delta State University,Abraka, Delta State

Login to access the Email id


Rights and Permissions

Background: Unlike Chronic Myeloid Leukemia (CML) whose genetic basis (the Philadelphia chromosome), has become a household name, that of Polycythaemia Vera and other non-leukemic myeloproliferative diseases has not equally received wide publicity. Aim: The aim of this paper is to review and highlight the role of JAK2 mutation in Polycythaemia Vera, Primary Myelofibrosis and Essential Thrombocythaemia. Methods: Literature on the subject was reviewed using manual library search, articles in journals, internet search and conference abstracts. Results: JAK2 mutation plays important role in the general pathophysiology of non-leukemic myeloproliferative diseases. Proper understanding of these roles is being utilized in research and development of novel therapeutic agents.


[PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1244    
    Printed18    
    Emailed0    
    PDF Downloaded114    
    Comments [Add]    

Recommend this journal