Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Home Print this page Email this page
Users Online:: 18908
ORIGINAL ARTICLE
Year : 2013  |  Volume : 16  |  Issue : 3  |  Page : 102-106

Bacterial isolates from the bronchoalveolar lavage fluid of patients with pneumonia not responding to initial antimicrobial therapy


1 Department of Pulmonary Medicine, Kasturba Medical College, Manipal University, Manipal, Karnataka, India
2 Department of Pharmacology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India
3 Department of Microbiology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India

Correspondence Address:
Rahul Magazine
Department of Pulmonary Medicine, Kasturba Medical College, Manipal University, Manipal, Karnataka - 576 104
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1118-8561.121914

Rights and Permissions

Background: Patients with community-acquired pneumonia (CAP) who are admitted in a hospital but do not respond to initial antimicrobial therapy pose a challenge to the attending physician. The knowledge of the likely pathogens and their sensitivity pattern can help the clinicians to better manage such cases. Aims and Objectives: To study the spectrum of the bacterial isolates and to determine the antimicrobial sensitivity pattern obtained from the bronchoalveolar lavage (BAL) fluid of CAP patients who did not respond to initial antimicrobial therapy. Setting and Design: A retrospective study of 87 patients who were admitted in the medical wards of a tertiary care teaching hospital in South India with the diagnosis of CAP and were not responding to initial antimicrobial therapy. Materials and Methods: The patient-related data were obtained from the case records and entered on a pre-designed proforma. This included demographic characteristics and reports of relevant clinical tests. The BAL culture and sensitivity results were also noted on the proforma. Results: The mean age of the patients was 49.28 ± 16.61 years (mean ± SD, range 17-80 years). Fifty-seven patients (65.5%) of were male. Also, 98 bacterial isolates were obtained from the BAL fluid of 87 patients. The most prevalent bacterial isolates included Pseudomonas aeruginosa (n = 35, 35.7%), Klebsiella pneumoniae (n = 19, 19.4%), Staphylococcus aureus (n = 15, 15.3%) and Acinetobacter species (n = 11, 11.2%). Most bacterial isolates tested showed 100% sensitivity to meropenem except Acinetobacter species (25%). Conclusion: P. aeruginosa and K. pneumoniae were the most common bacterial pathogens isolated from the BAL fluid. The isolates tested showed 100% sensitivity to meropenem except Acinetobacter species. All the methicillin-resistant S. aureus isolates displayed sensitivity to vancomycin, linezolid and teicoplanin.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed6092    
    Printed274    
    Emailed0    
    PDF Downloaded417    
    Comments [Add]    
    Cited by others 7    

Recommend this journal